バイオ分子創成化学研究室（田中知成研究室）
Synthetic and Biomolecular Chemistry Lab.
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RESEARCH
Glycotechnology based on Synthetic chemistry and Polymer chemistry
Research and technologies related to glycans, which are called the third life chain after nucleic acids and proteins, are immature compared to nucleic acids and proteins. Based on synthetic chemistry such as organic synthesis and enzymatic reactions, and polymer chemistry such as precise polymerization and photopolymerization, we aim to contribute to the development of glycotechnology through the elucidation and control of biological functions related to glycans and polysaccharides and the development of materials.
Reseach examples
Chemo-enzymatic synthesis of oligosaccharides
Methods for the production of useful oligosaccharides and glycoconjugates are developed through chemo-enzymatic synthesis of oligosaccharides combining chemical synthesis of saccharide derivatives in water and enzymatic glycosylations catalyzed by glycosidases.
Protecting-group-free synthesis of glycopolymers bearing biological oligosaccharides
Simple synthetic methods for glycopolymers which is applicable to biological oligosaccharides with complicated structures.
One-pot synthesis of glycopolymers using photopolymerization in water
One-pot synthesis of glycopolymers in water and under open-air condition has been achieved using novel monomer bearing a water-soluble active ester which is stable in water.
Aqueous one-pot and chemo-enzymatic synthesis of glycopolymers
One-pot synthesis of glycopolymers from unprotected sugars in aqueous condition has been achieved by combination with chemical synthesis in water, glycosidase-catalyzed glycosylation, and radical polymerization.
Studies of polysaccharides
Researches on biomass polysaccharides such as cellulose and biological polysaccharides such as glycosaminoglycans are ongoing.
Examples of non-glycan research
Polymer-coating of inorganic particles by photopolymerization
Polymer-coating of inorganic particles such as titania is developed by photopolymerization using ultraviolet ray and visible light.
Development of bone regeneration materials
Biomaterials such as bone regeneration materials are developed using natural polymers such as gelatin and plant-derived natural compounds such as catechin.
